Overcoming challenges to imaging and manipulating

neuronal activity with light

Brains are three-dimensional

but traditional microscopes image one plane at a time.
We are developing light field imaging systems that image an entire volume with a single camera frame.
IEEE Trans Imag Proc, 2024
IEEE Trans Comp Imag, 2023
IEEE Trans Comp Imag, 2022
Neurophotonics, 2022
Neurophotonics, 2020
IEEE Trans Comp Imag, 2020
Quicke Doctoral Thesis, 2019

Mammalian brains scatter light strongly

We image fluorophores that emit red light less scattered than shorter wavelengths
BioRxiv, 2020
Journal of Physics D: Applied Physics, 2019
and develop post-processing methods to mitigate blur caused by scattering. 
IEEE Trans on Comput Imaging, 2020
Quicke Doctoral Thesis, 2019
Biomedical Optics Express, 2018

Neurons communicate with small, rapid signals

Resolving the smallest and fastest of these signals requires high photon fluxes to overcome shot noise. We develop high photon budget neuronal imaging methods based on widefield,
Front Cell Neurosci, 2019
Journal of Physics D: Applied Physics, 2019
multifocal two-photon,
Biomedical Optics Express, 2018
and light field microscopy.
IEEE Trans on Comput Imaging, 2020
BioRxiv, 2020